Identifying low-dimensional sufficient structures in nonlinear sufficient dimension reduction (SDR) has long been a fundamental yet challenging problem. Most existing methods lack theoretical guarantees of exhaustiveness in identifying lower dimensional structures, either at the population level or at the sample level. We tackle this issue by proposing a new method, generative sufficient dimension reduction (GenSDR), which leverages modern generative models. We show that GenSDR is able to fully recover the information contained in the central $σ$-field at both the population and sample levels. In particular, at the sample level, we establish a consistency property for the GenSDR estimator from the perspective of conditional distributions, capitalizing on the distributional learning capabilities of deep generative models. Moreover, by incorporating an ensemble technique, we extend GenSDR to accommodate scenarios with non-Euclidean responses, thereby substantially broadening its applicability. Extensive numerical results demonstrate the outstanding empirical performance of GenSDR and highlight its strong potential for addressing a wide range of complex, real-world tasks.

Video recordings of open surgeries are greatly required for education and research purposes. However, capturing unobstructed videos is challenging since surgeons frequently block the camera field of view. To avoid occlusion, the positions and angles of the camera must be frequently adjusted, which is highly labor-intensive. Prior work has addressed this issue by installing multiple cameras on a shadowless lamp and arranging them to fully surround the surgical area. This setup increases the chances of some cameras capturing an unobstructed view. However, manual image alignment is needed in post-processing since camera configurations change every time surgeons move the lamp for optimal lighting. This paper aims to fully automate this alignment task. The proposed method identifies frames in which the lighting system moves, realigns them, and selects the camera with the least occlusion to generate a video that consistently presents the surgical field from a fixed perspective. A user study involving surgeons demonstrated that videos generated by our method were superior to those produced by conventional methods in terms of the ease of confirming the surgical area and the comfort during video viewing. Additionally, our approach showed improvements in video quality over existing techniques. Furthermore, we implemented several synthesis options for the proposed view-synthesis method and conducted a user study to assess surgeons' preferences for each option.

Recent interest in Multi-Agent Systems of Large Language Models (MAS LLMs) has led to an increase in frameworks leveraging multiple LLMs to tackle complex tasks. However, much of this literature appropriates the terminology of MAS without engaging with its foundational principles. In this position paper, we highlight critical discrepancies between MAS theory and current MAS LLMs implementations, focusing on four key areas: the social aspect of agency, environment design, coordination and communication protocols, and measuring emergent behaviours. Our position is that many MAS LLMs lack multi-agent characteristics such as autonomy, social interaction, and structured environments, and often rely on oversimplified, LLM-centric architectures. The field may slow down and lose traction by revisiting problems the MAS literature has already addressed. Therefore, we systematically analyse this issue and outline associated research opportunities; we advocate for better integrating established MAS concepts and more precise terminology to avoid mischaracterisation and missed opportunities.

This paper investigates the optimization of Truncated Backpropagation Through Time (TBPTT) for training neural networks in digital audio effect modeling, with a focus on dynamic range compression. The study evaluates key TBPTT hyperparameters -- sequence number, batch size, and sequence length -- and their influence on model performance. Using a convolutional-recurrent architecture, we conduct extensive experiments across datasets with and without conditionning by user controls. Results demonstrate that carefully tuning these parameters enhances model accuracy and training stability, while also reducing computational demands. Objective evaluations confirm improved performance with optimized settings, while subjective listening tests indicate that the revised TBPTT configuration maintains high perceptual quality.

Geometric Graph Neural Networks (GNNs) and Transformers have become state-of-the-art for learning from 3D protein structures. However, their reliance on message passing prevents them from capturing the hierarchical interactions that govern protein function, such as global domains and long-range allosteric regulation. In this work, we argue that the network architecture itself should mirror this biological hierarchy. We introduce Geometric Graph U-Nets, a new class of models that learn multi-scale representations by recursively coarsening and refining the protein graph. We prove that this hierarchical design can theoretically more expressive than standard Geometric GNNs. Empirically, on the task of protein fold classification, Geometric U-Nets substantially outperform invariant and equivariant baselines, demonstrating their ability to learn the global structural patterns that define protein folds. Our work provides a principled foundation for designing geometric deep learning architectures that can learn the multi-scale structure of biomolecules.

We demonstrate the utility of this resource and accompanying metamodel through application to existing legal frameworks and industry standards, offering insights for comparative framework analysis. Applications include compliance policy enforcement, compliance monitoring, data discovery, and risk assessment.

Multimodal large language models (MLLMs) are increasingly deployed in real-world, agentic settings where outputs must not only be correct, but also conform to predefined data schemas. Despite recent progress in structured generation in textual domain, there is still no benchmark that systematically evaluates schema-grounded information extraction and reasoning over visual inputs. In this work, we conduct a comprehensive study of visual structural output capabilities for MLLMs with our carefully designed SO-Bench benchmark. Covering four visual domains, including UI screens, natural images, documents, and charts, SO-Bench is built from over 6.5K diverse JSON schemas and 1.8K curated image-schema pairs with human-verified quality. Benchmarking experiments on open-sourced and frontier proprietary models reveal persistent gaps in predicting accurate, schema compliant outputs, highlighting the need for better multimodal structured reasoning. Beyond benchmarking, we further conduct training experiments to largely improve the model's structured output capability. We plan to make the benchmark available to the community.

This article presents the first systematic review of unsupervised and semi-supervised computational text-based ideal point estimation (CT-IPE) algorithms, methods designed to infer latent political positions from textual data. These algorithms are widely used in political science, communication, computational social science, and computer science to estimate ideological preferences from parliamentary speeches, party manifestos, and social media. Over the past two decades, their development has closely followed broader NLP trends -- beginning with word-frequency models and most recently turning to large language models (LLMs). While this trajectory has greatly expanded the methodological toolkit, it has also produced a fragmented field that lacks systematic comparison and clear guidance for applied use. To address this gap, we identified 25 CT-IPE algorithms through a systematic literature review and conducted a manual content analysis of their modeling assumptions and development contexts. To compare them meaningfully, we introduce a conceptual framework that distinguishes how algorithms generate, capture, and aggregate textual variance. On this basis, we identify four methodological families -- word-frequency, topic modeling, word embedding, and LLM-based approaches -- and critically assess their assumptions, interpretability, scalability, and limitations. Our review offers three contributions. First, it provides a structured synthesis of two decades of algorithm development, clarifying how diverse methods relate to one another. Second, it translates these insights into practical guidance for applied researchers, highlighting trade-offs in transparency, technical requirements, and validation strategies that shape algorithm choice. Third, it emphasizes that differences in estimation outcomes across algorithms are themselves informative, underscoring the need for systematic benchmarking.

Self-adaptive systems (SASs) are designed to handle changes and uncertainties through a feedback loop with four core functionalities: monitoring, analyzing, planning, and execution. Recently, generative artificial intelligence (GenAI), especially the area of large language models, has shown impressive performance in data comprehension and logical reasoning. These capabilities are highly aligned with the functionalities required in SASs, suggesting a strong potential to employ GenAI to enhance SASs. However, the specific benefits and challenges of employing GenAI in SASs remain unclear. Yet, providing a comprehensive understanding of these benefits and challenges is complex due to several reasons: limited publications in the SAS field, the technological and application diversity within SASs, and the rapid evolution of GenAI technologies. To that end, this paper aims to provide researchers and practitioners a comprehensive snapshot that outlines the potential benefits and challenges of employing GenAI's within SAS. Specifically, we gather, filter, and analyze literature from four distinct research fields and organize them into two main categories to potential benefits: (i) enhancements to the autonomy of SASs centered around the specific functions of the MAPE-K feedback loop, and (ii) improvements in the interaction between humans and SASs within human-on-the-loop settings. From our study, we outline a research roadmap that highlights the challenges of integrating GenAI into SASs. The roadmap starts with outlining key research challenges that need to be tackled to exploit the potential for applying GenAI in the field of SAS. The roadmap concludes with a practical reflection, elaborating on current shortcomings of GenAI and proposing possible mitigation strategies.

Structure-based drug design (SBDD) focuses on designing small-molecule ligands that bind to specific protein pockets. Computational methods are integral in modern SBDD workflows and often make use of virtual screening methods via docking or pharmacophore search. Modern generative modeling approaches have focused on improving novel ligand discovery by enabling de novo design. In this work, we recognize that these tasks share a common structure and can therefore be represented as different instantiations of a consistent generative modeling framework. We propose a unified approach in OMTRA, a multi-modal flow matching model that flexibly performs many tasks relevant to SBDD, including some with no analogue in conventional workflows. Additionally, we curate a dataset of 500M 3D molecular conformers, complementing protein-ligand data and expanding the chemical diversity available for training. OMTRA obtains state of the art performance on pocket-conditioned de novo design and docking; however, the effects of large-scale pretraining and multi-task training are modest. All code, trained models, and dataset for reproducing this work are available at https://github.com/gnina/OMTRA